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Miklos Gratzl

Associate Professor, Biomedical Engineering
Researches biomedical sensors and diagnostics, and focuses on translation to clinical applications
Office: 425 Wickenden
Phone Number: (216) 368-6589
Fax Number: (216) 368-4969

Education

Ph.D., electroanalytical chemistry and microsensing, Hungarian Aacademy of Science and Techn. U. of Budapest, 1984

Research Interests

basic biomedical research that requires among others, biomedical sensing expertise; applied research which can lead to translation to clinical applications and inventions of commercial value in the area of sensing and diagnostics

Teaching Interests

undergraduate and graduate biomedical instrumentation; undergraduate research including senior project; specialty graduate course on biomedical sensing

Publications

Zhang, Z., Cserfalvi, T., & Gratzl, M. (2019). pH dependent voltammetry at partially oxidized palladium and its potential for voltammetry-based pH sensing. Journal of Electroanalytical Chemistry, 845 (), 1-5.
Sheth, D., & Gratzl, M. (2019). Electrochemical mapping of oxygenation in the three-dimensional multicellular tumour hemi-spheroid. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 475 (2225).
Ahuja, P., Nair, S., Narayan, S., & Gratzl, M. (2015). Functional Imaging of Chemically Active Surfaces with Optical Reporter Microbeads. , 10 (9), -.
Sheth, D., & Gratzl, M. (2013). Differential linear scan voltammetry: analytical performance in comparison with pulsed voltammetry techniques.. Analytical and bioanalytical chemistry, 405 (16), 5539-47.
Lee, K., Hubbard, L., Hernandez, C., Yildiz, S., Gratzl, M., & Steinmetz, N. (2013). Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct.. Biomaterials science, 1 (6).
Pähler, M., Schuhmann, W., & Gratzl, M. (2011). Simultaneous visualization of surface topography and concentration field by means of scanning electrochemical microscopy using a single electrochemical probe and impedance spectroscopy.. Chemphyschem : a European journal of chemical physics and physical chemistry, 12 (15), 2798-805.
Nair, S., Kashyap, V., Laboisse, C., Hopfer, U., & Gratzl, M. (2011). Time-resolved release of calcium from an epithelial cell monolayer during mucin secretion.. European biophysics journal : EBJ, 40 (2), 165-74.
Oruganti, P., & Gratzl, M. (2009). Temporal ratiometry to assess dynamic concentration distributions of fluorescent molecules in single live cells during continuous diffusional dosing.. Analytical and bioanalytical chemistry, 395 (2), 449-56.
Sunna, A., Hutarew, G., Gradl, J., Gratzl, M., Denz, H., & Fiegl, M. (2009). Successful antiangiogenic combination therapy for pseudomyxoma peritonei with bevacizumab and capecitabine.. Cancer biology & therapy, 8 (15), 1459-62.
Kao, L., & Gratzl, M. (2009). Serum cholinesterase assay using a reagent-free micro pH-stat.. Analytical biochemistry, 389 (2), 93-6.
Sheth, D., Diefes, R., & Gratzl, M. (2009). Spatially averaging electrodes.. Analytical chemistry, 81 (6), 2129-34.
Lazarov, N., Reindl, S., Fischer, F., & Gratzl, M. (2009). Histaminergic and dopaminergic traits in the human carotid body.. Respiratory physiology & neurobiology, 165 (2-3), 131-6.
Gratzl, M., Yi, C., & Bright, G. (2008). Continuous and quantitative delivery of molecules into individual cells with a diffusional microburet.. Analytical chemistry, 80 (23), 9310-5.
Kao, L., Shetty, G., & Gratzl, M. (2008). Determination of critical micelle concentration with the rotating sample system.. Analytical and bioanalytical chemistry, 392 (7-8), 1391-6.
Nair, S., & Gratzl, M. (2008). Effects of sampling rate on the interpretation of cellular transport measurements.. Analytical chemistry, 80 (20), 7684-9.
Yoshida, M., Tohda, K., & Gratzl, M. (2008). Controlled diffusion for laboratory solution preparation.. Analytical and bioanalytical chemistry, 392 (3), 471-7.
Kao, L., Hsu, H., & Gratzl, M. (2008). Reagentless pH-stat for microliter fluid specimens.. Analytical chemistry, 80 (11), 4065-9.
Nair, S., Kashyap, V., Laboisse, C., Hopfer, U., & Gratzl, M. (2008). Time resolved secretion of chloride from a monolayer of mucin-secreting epithelial cells.. European biophysics journal : EBJ, 37 (4), 411-9.
Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007). Enterochromaffin cells of the human gut: sensors for spices and odorants.. Gastroenterology, 132 (5), 1890-901.
Oruganti, P., & Gratzl, M. (2007). Rate-limiting hydrodynamic resistance for controlled reagent delivery for laboratory solution preparation.. Analytical chemistry, 79 (6), 2541-5.
Lazarov, N., Rozloznik, M., Reindl, S., Rey-Ares, V., Dutschmann, M., & Gratzl, M. (2006). Expression of histamine receptors and effect of histamine in the rat carotid body chemoafferent pathway.. The European journal of neuroscience, 24 (12), 3431-44.
Lazarov, N., & Gratzl, M. (2006). Selective expression of histamine receptors in rat mesencephalic trigeminal neurons.. Neuroscience letters, 404 (1-2), 67-71.
Tohda, K., & Gratzl, M. (2006). Micro-miniature autonomous optical sensor array for monitoring ions and metabolites 2: color responses to pH, K+ and glucose.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 22 (7), 937-41.
Tohda, K., & Gratzl, M. (2006). Micro-miniature autonomous optical sensor array for monitoring ions and metabolites 1: design, fabrication, and data analysis.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 22 (3), 383-8.
Shetty, G., Syed, T., Tohda, K., & Gratzl, M. (2005). Hydrodynamic electrochemistry in 20 microL drops in the rotating sample system.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 21 (10), 1155-60.
Ngendahimana, D., Gamel-Didelon, K., Jung, H., Tolnay, M., Lüdecke, D., Gratzl, M., ... Mayerhofer, A. (2005). Receptors and sites of synthesis and storage of gamma-aminobutyric acid in human pituitary glands and in growth hormone adenomas.. American journal of clinical pathology, 124 (4), 550-8.
Nair, S., & Gratzl, M. (2005). Deconvolution of concentration recordings at live cell preparations via shape error optimization.. Analytical chemistry, 77 (9), 2875-81.
Koerner, P., Hesslinger, C., Schaefermeyer, A., Prinz, C., & Gratzl, M. (2004). Evidence for histamine as a transmitter in rat carotid body sensor cells.. Journal of neurochemistry, 91 (2), 493-500.
Schäfermeyer, A., Gratzl, M., Andrade, R., Dossumbekova, A., Sachs, G., & Prinz, C. (2004). Isolation and receptor profiling of ileal enterochromaffin cells.. Acta physiologica Scandinavica, 182 (1), 53-62.
Metzeler, K., Agoston, A., & Gratzl, M. (2004). An Intrinsic gamma-aminobutyric acid (GABA)ergic system in the adrenal cortex: findings from human and rat adrenal glands and the NCI-H295R cell line.. Endocrinology, 145 (5), 2402-11.
Zanner, R., Gratzl, M., & Prinz, C. (2004). Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells.. Journal of cell science, 117 (Pt 11), 2369-76.
Gratzl, M., Breckner, M., & Prinz, C. (2004). Mechanisms of storage and exocytosis in neuroendocrine tumors.. Endocrine pathology, 15 (1), 1-16.
Yoshida, M., Tohda, K., & Gratzl, M. (2003). Optical detection in microscopic domains. 3. Confocal analysis of fluorescent amphiphilic molecules.. Analytical chemistry, 75 (22), 6133-40.
Yoshida, M., Tohda, K., & Gratzl, M. (2003). Hydrodynamic micromanipulation of individual cells onto patterned attachment sites on biomicroelectromechanical system chips.. Analytical chemistry, 75 (17), 4686-90.
Gamel-Didelon, K., Kunz, L., Fohr, K., Gratzl, M., & Mayerhofer, A. (2003). Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells.. The Journal of biological chemistry, 278 (22), 20192-5.
Tohda, K., & Gratzl, M. (2003). A microscopic, continuous, optical monitor for interstitial electrolytes and glucose.. Chemphyschem : a European journal of chemical physics and physical chemistry, 4 (2), 155-60.
Prinz, C., Zanner, R., & Gratzl, M. (2003). Physiology of gastric enterochromaffin-like cells.. Annual review of physiology, 65 (), 371-82.
Zanner, R., Gratzl, M., & Prinz, C. (2002). Circle of life of secretory vesicles in gastric enterochromaffin-like cells.. Annals of the New York Academy of Sciences, 971 (), 389-96.
Gamel-Didelon, K., Corsi, C., Pepeu, G., Jung, H., Gratzl, M., & Mayerhofer, A. (2002). An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels.. Neuroendocrinology, 76 (3), 170-7.
Graff, L., Frungieri, M., Zanner, R., Pohlinger, A., Prinz, C., & Gratzl, M. (2002). Expression of histidine decarboxylase and synthesis of histamine by human small cell lung carcinoma.. The American journal of pathology, 160 (5), 1561-5.
Zanner, R., Hapfelmeier, G., Gratzl, M., & Prinz, C. (2002). Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells.. American journal of physiology. Cell physiology, 282 (2), C374-82.
Cserey, A., & Gratzl, M. (2001). Stationary-state oxidized platinum microsensor for selective and on-line monitoring of nitric oxide in biological preparations.. Analytical chemistry, 73 (16), 3965-74.
Tohda, K., Lu, S., Umezawa, Y., & Gratzl, M. (2001). Optical detection in microscopic domains. 2. Inner filter effects for monitoring nonfluorescent molecules with fluorescence.. Analytical chemistry, 73 (9), 2070-7.
Mayerhofer, A., Höhne-Zell, B., Gamel-Didelon, K., Jung, H., Redecker, P., Grube, D., ... Gratzl, M. (2001). Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15 (6), 1089-91.
Graff, L., Castrop, F., Bauer, M., Höfler, H., & Gratzl, M. (2001). Expression of vesicular monoamine transporters, synaptosomal-associated protein 25 and syntaxin1: a signature of human small cell lung carcinoma.. Cancer research, 61 (5), 2138-44.
Grosse, J., Bulling, A., Brucker, C., Herberg, S., Amsterdam, A., Mayerhofer, A., ... Gratzl, M. (2000). Synaptosome-associated protein of 25 kilodaltons in oocytes and steroid-producing cells of rat and human ovary: molecular analysis and regulation by gonadotropins.. Biology of reproduction, 63 (2), 643-50.
Bulling, A., Rothenberg, F., Herberg, S., Duffy, D., Stouffer, R., Ojeda, S., ... Mayerhofer, A. (2000). Identification of an ovarian voltage-activated Na+-channel type: hints to involvement in luteolysis.. Molecular endocrinology (Baltimore, Md.), 14 (7), 1064-74.
Lu, S., & Gratzl, M. (2000). Optical detection in microscopic domains. 1. Monitoring chemical manipulations with absorption microspectrometry.. Analytical chemistry, 72 (7), 1569-75.
Lu, S., Matsumoto, T., & Gratzl, M. (1999). Fine chemical manipulations of microscopic liquid samples. 2. Consuming and nonconsuming schemes.. Analytical chemistry, 71 (21), 4896-902.
Prinz, C., Zanner, R., Gerhard, M., Mahr, S., Neumayer, N., Höhne-Zell, B., ... Gratzl, M. (1999). The mechanism of histamine secretion from gastric enterochromaffin-like cells.. The American journal of physiology, 277 (5), C845-55.
Gratzl, M., Lu, S., Matsumoto, T., Yi, C., & Bright, G. (1999). Fine chemical manipulations of microscopic liquid samples. 1. Droplet loading with chemicals.. Analytical chemistry, 71 (14), 2751-6.
Lu, S., & Gratzl, M. (1999). Monitoring drug efflux from sensitive and multidrug-resistant single cancer cells with microvoltammetry.. Analytical chemistry, 71 (14), 2821-30.
Kashyap, V., & Gratzl, M. (1999). Adjusting the distance of electrochemical microsensors from secreting cell monolayers on the micrometer scale using impedance.. Analytical chemistry, 71 (14), 2814-20.
Grosse, G., Grosse, J., Tapp, R., Kuchinke, J., Gorsleben, M., Fetter, I., ... Bergmann, M. (1999). SNAP-25 requirement for dendritic growth of hippocampal neurons.. Journal of neuroscience research, 56 (5), 539-46.
Bulling, A., Brucker, C., Herberg, S., Gratzl, M., & Mayerhofer, A. (1999). Identification of voltage-activated Na+ and K+ channels in human steroid-secreting ovarian cells.. Annals of the New York Academy of Sciences, 868 (), 77-9.
Yi, C., Saidel, G. M., & Gratzl, M. (1999). Single cell model for simultaneous drug delivery and efflux.. Annals of biomedical engineering, 27 (2), 208-18.
Yi, C., Saidel, G. M., & Gratzl, M. (1999). Single cell model for simultaneous drug delivery and efflux.. Annals of biomedical engineering, 27 (2), 208-18.
Banaschewski, C., Höhne-Zell, B., Ovtscharoff, W., & Gratzl, M. (1998). Characterization of vesicular membrane-bound alpha-SNAP and NSF in adrenal chromaffin cells.. Biochemistry, 37 (47), 16719-27.
Yi, C., & Gratzl, M. (1998). Continuous in situ electrochemical monitoring of doxorubicin efflux from sensitive and drug-resistant cancer cells.. Biophysical journal, 75 (5), 2255-61.
Praveen Kumar, G., Overholt, J., Bright, G., Huisman, H., Lu, S., Gratzl, M., ... Prabhakar, N. (1998). Release of dopamine and norepinephrine by hypoxia from PC-12 cells.. The American journal of physiology, 274 (6), C1592-600.
Kashyap, V., & Gratzl, M. (1998). Electrochemistry in microscopic domains. 1. The electrochemical cell and its voltammetric and amperometric response.. Analytical chemistry, 70 (8), 1468-76.
Grosse, G., Tapp, R., Wartenberg, M., Sauer, H., Fox, P., Grosse, J., ... Bergmann, M. (1998). Prenatal hippocampal granule cells in primary cell culture form mossy fiber boutons at pyramidal cell dendrites.. Journal of neuroscience research, 51 (5), 602-11.
Höhne-Zell, B., Galler, A., Schepp, W., Gratzl, M., & Prinz, C. (1997). Functional importance of synaptobrevin and SNAP-25 during exocytosis of histamine by rat gastric enterochromaffin-like cells.. Endocrinology, 138 (12), 5518-26.
Cserey, A., & Gratzl, M. (1997). Rotating sample system: an equivalent of a rotating electrode for microliter samples.. Analytical chemistry, 69 (18), 3687-92.
Höhne-Zell, B., & Gratzl, M. (1996). Adrenal chromaffin cells contain functionally different SNAP-25 monomers and SNAP-25/syntaxin heterodimers.. FEBS letters, 394 (2), 109-16.
Yi, C., Huang, D., & Gratzl, M. (1996). Complexometric determination of metal ions by microscopic diffusional titration.. Analytical chemistry, 68 (9), 1580-4.
Mayerhofer, A., Lahr, G., Seidl, K., Eusterschulte, B., Christopherson, W., & Gratzl, M. (1996). The neural cell adhesion molecule (NCAM) provides clues to the development of testicular Leydig cells.. Journal of andrology, 17 (3), 223-30.
Grabs, D., Bergmann, M., Urban, M., Post, A., & Gratzl, M. (1996). Rab3 proteins and SNAP-25, essential components of the exocytosis machinery in conventional synapses, are absent from ribbon synapses of the mouse retina.. The European journal of neuroscience, 8 (1), 162-8.
Ginda, W., Gratzl, M., Mayerhofer, A., & Warchoł, J. (1996). Chromogranin A immunoreactivity in epithelial cells of the thymus.. Folia histochemica et cytobiologica, 34 (2), 91-3.
Lehmann-Klose, S., Beinbrech, B., Cuppoletti, J., Gratzl, M., Rüegg, J., & Pfitzer, G. (1995). Ca(2+)- and GTP[gamma S]-induced translocation of the glucose transporter, GLUT-4, to the plasma membrane of permeabilized cardiomyocytes determined using a novel immunoprecipitation method.. Pflugers Archiv : European journal of physiology, 430 (3), 333-9.
Mayerhofer, A., Engling, R., Stecher, B., Decker, M., Sterzik, K., & Gratzl, M. (1995). Relaxin triggers calcium transients in human granulosa-lutein cells.. European journal of endocrinology, 132 (4), 507-13.
Totzauer, I., Amselgruber, W., Sinowatz, F., & Gratzl, M. (1995). Early expression of chromogranin A and tyrosine hydroxylase during prenatal development of the bovine adrenal gland.. Anatomy and embryology, 191 (2), 139-43.
Höhne-Zell, B., Decker, M., Weller, U., & Gratzl, M. (1994). Synaptobrevin cleavage by the tetanus toxin light chain is linked to the inhibition of exocytosis in chromaffin cells.. FEBS letters, 355 (2), 131-4.
Gratzl, M. (1994). Molecular aspects of secretory granule exocytosis by neurons and endocrine cells.. Annals of the New York Academy of Sciences, 733 (), 223-32.
Mayerhofer, A., Lahr, G., Fröhlich, U., Zienecker, R., Sterzik, K., & Gratzl, M. (1994). Expression and alternative splicing of the neural cell adhesion molecule NCAM in human granulosa cells during luteinization.. FEBS letters, 346 (2-3), 207-12.
Dayanithi, G., Stecher, B., Höhne-Zell, B., Yamasaki, S., Binz, T., Weller, U., ... Gratzl, M. (1994). Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals.. Neuroscience, 58 (2), 423-31.
Höhne-Zell, B., Stecher, B., & Gratzl, M. (1993). Functional characterization of the catalytic site of the tetanus toxin light chain using permeabilized adrenal chromaffin cells.. FEBS letters, 336 (1), 175-80.
Mayerhofer, A., Sterzik, K., Link, H., Wiemann, M., & Gratzl, M. (1993). Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells.. The Journal of clinical endocrinology and metabolism, 77 (5), 1209-14.
Bergmann, M., Schuster, T., Grabs, D., Marquèze-Pouey, B., Betz, H., Traurig, H., ... Gratzl, M. (1993). Synaptophysin and synaptoporin expression in the developing rat olfactory system.. Brain research. Developmental brain research, 74 (2), 235-44.
Mendelowitsch, A., Zhang, J., Vereczkey, C., Gratzl, M., & Gratzl, M. (1993). Long-term survival of autologous adrenal medulla grafts in the great omentum of the rat.. Neurological research, 15 (4), 269-72.
Ovtscharoff, W., Bergmann, M., Marquèze-Pouey, B., Knaus, P., Betz, H., Grabs, D., ... Gratzl, M. (1993). Ontogeny of synaptophysin and synaptoporin in the central nervous system: differential expression in striatal neurons and their afferents during development.. Brain research. Developmental brain research, 72 (2), 219-25.
Lahr, G., Mayerhofer, A., Bucher, S., Barthels, D., Wille, W., & Gratzl, M. (1993). Neural cell adhesion molecules in rat endocrine tissues and tumor cells: distribution and molecular analysis.. Endocrinology, 132 (3), 1207-17.
Fohr, K., Mayerhofer, A., Sterzik, K., Rudolf, M., Rosenbusch, B., & Gratzl, M. (1993). Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells: evidence for the presence of a functional alpha-adrenergic receptor.. The Journal of clinical endocrinology and metabolism, 76 (2), 367-73.
Link, H., Dayanithi, G., & Gratzl, M. (1993). Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients.. Endocrinology, 132 (2), 873-8.
Fohr, K., Warchol, W., & Gratzl, M. (1993). Calculation and control of free divalent cations in solutions used for membrane fusion studies.. Methods in enzymology, 221 (), 149-57.
Ahnert-Hilger, G., Stecher, B., Beyer, F., & Gratzl, M. (1993). Exocytotic membrane fusion as studied in toxin-permeabilized cells.. Methods in enzymology, 221 (), 139-49.
Stecher, B., Hens, J., Weller, U., Gratzl, M., Gispen, W., & De Graan, P. (1992). Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin.. FEBS letters, 312 (2-3), 192-4.
Mayerhofer, A., Fohr, K., Sterzik, K., & Gratzl, M. (1992). Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells.. The Journal of endocrinology, 135 (1), 153-9.
Mayerhofer, A., Seidl, K., Lahr, G., Bitter-Suermann, D., Christopherson, W., Barthels, D., ... Gratzl, M. (1992). Leydig cells express neural cell adhesion molecules in vivo and in vitro.. Biology of reproduction, 47 (4), 656-64.
Mayerhofer, A., Spanel-Borowski, K., Watkins, S., & Gratzl, M. (1992). Cultured microvascular endothelial cells derived from the bovine corpus luteum possess NCAM-140.. Experimental cell research, 201 (2), 545-8.
Lahr, G., Mayerhofer, A., Bergmann, M., Takiyyuddin, M., & Gratzl, M. (1992). Chromogranin A in neurons of the rat cerebellum and spinal cord: quantification and sites of expression.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40 (7), 993-9.
Lahr, G., Mayerhofer, A., Seidl, K., Bucher, S., Grothe, C., Knöchel, W., ... Gratzl, M. (1992). Basic fibroblast growth factor (bFGF) in rodent testis. Presence of bFGF mRNA and of a 30 kDa bFGF protein in pachytene spermatocytes.. FEBS letters, 302 (1), 43-6.
Stecher, B., Ahnert-Hilger, G., Weller, U., Kemmer, T., & Gratzl, M. (1992). Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin.. The Biochemical journal, 283 ( Pt 3) (), 899-904.
Dayanithi, G., Weller, U., Ahnert-Hilger, G., Link, H., Nordmann, J., & Gratzl, M. (1992). The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings.. Neuroscience, 46 (2), 489-93.
Fohr, K., Wahl, Y., Engling, R., Kemmer, T., & Gratzl, M. (1991). Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells.. Cell calcium, 12 (10), 735-42.
Mayerhofer, A., Lahr, G., & Gratzl, M. (1991). Expression of the neural cell adhesion molecule in endocrine cells of the ovary.. Endocrinology, 129 (2), 792-800.
Mayerhofer, A., Russell, L., Grothe, C., Rudolf, M., & Gratzl, M. (1991). Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes.. Endocrinology, 129 (2), 921-4.
Fohr, K., Ahnert-Hilger, G., Stecher, B., Scott, J., & Gratzl, M. (1991). GTP and Ca2+ modulate the inositol 1,4,5-trisphosphate-dependent Ca2+ release in streptolysin O-permeabilized bovine adrenal chromaffin cells.. Journal of neurochemistry, 56 (2), 665-70.
Gratzl, M., Tarcali, J., Pungor, E., & Juhász, G. (1991). Local depletion of monoamines induced with in vivo voltammetry in the cat brain.. Neuroscience, 41 (1), 287-93.
Engling, R., Fohr, K., Kemmer, T., & Gratzl, M. (1991). Effect of GTP and Ca2+ on inositol 1,4,5-trisphosphate induced Ca2+ release from permeabilized rat exocrine pancreatic acinar cells.. Cell calcium, 12 (1), 1-9.
Bergmann, M., Lahr, G., Mayerhofer, A., & Gratzl, M. (1991). Expression of synaptophysin during the prenatal development of the rat spinal cord: correlation with basic differentiation processes of neurons.. Neuroscience, 42 (2), 569-82.
Aletsee-Ufrecht, M., Langley, K., Gratzl, M., & Gratzl, M. (1990). Differential expression of the neural cell adhesion molecule NCAM 140 in human pituitary tumors.. FEBS letters, 272 (1-2), 45-9.
Aletsee-Ufrecht, M., Langley, K., Rotsch, M., Havemann, K., & Gratzl, M. (1990). NCAM: a surface marker for human small cell lung cancer cells.. FEBS letters, 267 (2), 295-300.
Ehrhart, M., & Gratzl, M. (1990). Chromogranin A in the endocrine pancreas: extracellular or intracellular function?. Acta histochemica. Supplementband, 38 (), 87-91.
Lahr, G., Heiss, C., Mayerhofer, A., Schilling, K., Parmer, R., O'Connor, D., ... Gratzl, M. (1990). Chromogranin A in the olfactory system of the rat.. Neuroscience, 39 (3), 605-11.
Aletsee-Ufrecht, M., Langley, O., & Gratzl, M. (1990). NCAM expression in endocrine cells.. Acta histochemica. Supplementband, 38 (), 45-50.
Dayanithi, G., Ahnert-Hilger, G., Weller, U., Nordmann, J., & Gratzl, M. (1990). Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin.. Neuroscience, 39 (3), 711-5.
Wegenhorst, U., Gratzl, M., Fohr, K., & Ahnert-Hilger, G. (1989). Millimolar concentrations of free magnesium enhance exocytosis from permeabilized rat pheochromocytoma (PC 12) cells.. Neuroscience letters, 106 (3), 300-4.
Stecher, B., Weller, U., Habermann, E., Gratzl, M., & Ahnert-Hilger, G. (1989). The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells.. FEBS letters, 255 (2), 391-4.
Fohr, K., Scott, J., Ahnert-Hilger, G., & Gratzl, M. (1989). Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate.. The Biochemical journal, 262 (1), 83-9.
Langley, O., Aletsee-Ufrecht, M., Grant, N., & Gratzl, M. (1989). Expression of the neural cell adhesion molecule NCAM in endocrine cells.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 37 (6), 781-91.
Ahnert-Hilger, G., Bader, M., Bhakdi, S., & Gratzl, M. (1989). Introduction of macromolecules into bovine adrenal medullary chromaffin cells and rat pheochromocytoma cells (PC12) by permeabilization with streptolysin O: inhibitory effect of tetanus toxin on catecholamine secretion.. Journal of neurochemistry, 52 (6), 1751-8.
Stecher, B., Gratzl, M., & Ahnert-Hilger, G. (1989). Reductive chain separation of botulinum A toxin--a prerequisite to its inhibitory action on exocytosis in chromaffin cells.. FEBS letters, 248 (1-2), 23-7.
Ahnert-Hilger, G., Weller, U., Dauzenroth, M., Habermann, E., & Gratzl, M. (1989). The tetanus toxin light chain inhibits exocytosis.. FEBS letters, 242 (2), 245-8.
Ahnert-Hilger, G., Mach, W., Fohr, K., & Gratzl, M. (1989). Poration by alpha-toxin and streptolysin O: an approach to analyze intracellular processes.. Methods in cell biology, 31 (), 63-90.
Schilling, K., & Gratzl, M. (1988). Quantification of p38/synaptophysin in highly purified adrenal medullary chromaffin vesicles.. FEBS letters, 233 (1), 22-4.
Ahnert-Hilger, G., & Gratzl, M. (1988). Controlled manipulation of the cell interior by pore-forming proteins.. Trends in pharmacological sciences, 9 (6), 195-7.
Ehrhart, M., Jörns, A., Grube, D., & Gratzl, M. (1988). Cellular distribution and amount of chromogranin A in bovine endocrine pancreas.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 36 (5), 467-72.
Ahnert-Hilger, G., Bräutigam, M., & Gratzl, M. (1987). Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins.. Biochemistry, 26 (24), 7842-8.
Ahnert-Hilger, G., & Gratzl, M. (1987). Further characterization of dopamine release by permeabilized PC12 cells.. Journal of neurochemistry, 49 (3), 764-70.
Langley, O., Aletsee-Ufrecht, M., & Gratzl, M. (1987). Endocrine cells share expression of N-CAM with neurones.. FEBS letters, 220 (1), 108-12.
Linderman, J., Ahnert-Hilger, G., Fuchs, G., & Gratzl, M. (1987). Purification of alpha-toxin from Staphylococcus aureus and application to cell permeabilization.. Analytical biochemistry, 164 (1), 84-9.
Yoshie, S., Hagn, C., Ehrhart, M., Fischer-Colbrie, R., Grube, D., Winkler, H., ... Gratzl, M. (1987). Immunological characterization of chromogranins A and B and secretogranin II in the bovine pancreatic islet.. Histochemistry, 87 (2), 99-106.
Ehrhart, M., Grube, D., Bader, M., Aunis, D., & Gratzl, M. (1986). Chromogranin A in the pancreatic islet: cellular and subcellular distribution.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 34 (12), 1673-82.
Reiffen, F., & Gratzl, M. (1986). Ca2+ binding to chromaffin vesicle matrix proteins: effect of pH, Mg2+, and ionic strength.. Biochemistry, 25 (15), 4402-6.
Bader, M., Thiersé, D., Aunis, D., Ahnert-Hilger, G., & Gratzl, M. (1986). Characterization of hormone and protein release from alpha-toxin-permeabilized chromaffin cells in primary culture.. The Journal of biological chemistry, 261 (13), 5777-83.
Saermark, T., & Gratzl, M. (1986). Na+/Ca2+ exchange in coated microvesicles.. The Biochemical journal, 233 (3), 643-8.
Reiffen, F., & Gratzl, M. (1986). Chromogranins, widespread in endocrine and nervous tissue, bind Ca2+.. FEBS letters, 195 (1-2), 327-30.
Bulenda, D., & Gratzl, M. (1985). Matrix free Ca2+ in isolated chromaffin vesicles.. Biochemistry, 24 (26), 7760-5.
Ahnert-Hilger, G., Bhakdi, S., & Gratzl, M. (1985). Minimal requirements for exocytosis. A study using PC 12 cells permeabilized with staphylococcal alpha-toxin.. The Journal of biological chemistry, 260 (23), 12730-4.
Ahnert-Hilger, G., Bhakdi, S., & Gratzl, M. (1985). Alpha-toxin permeabilized rat pheochromocytoma cells: a new approach to investigate stimulus-secretion coupling.. Neuroscience letters, 58 (1), 107-10.
Gratzl, M. (1984). Distribution of chromaffin secretory vesicles, acetylcholinesterase, and lysosomal enzymes in sucrose and Percoll gradients.. Analytical biochemistry, 142 (1), 148-54.
Krieger-Brauer, H., & Gratzl, M. (1983). Effects of monovalent and divalent cations on Ca2+ fluxes across chromaffin secretory membrane vesicles.. Journal of neurochemistry, 41 (5), 1269-76.
Gratzl, M., Russell, J., & Thornton, A. (1983). Stimulation-dependent uptake of an extracellular marker to subcellular fractions of isolated neurohypophysial tissue.. Experientia, 39 (9), 1007-9.
Saermark, T., Thornton, A., & Gratzl, M. (1983). Calcium/sodium exchange in purified secretory vesicles from bovine neurohypophyses.. Cell calcium, 4 (3), 151-70.
Saermark, T., Krieger-Brauer, H., Thornton, A., & Gratzl, M. (1983). Ca2+ uptake to purified secretory vesicles from bovine neurohypophyses.. Biochimica et biophysica acta, 727 (2), 239-45.
Krieger-Brauer, H., & Gratzl, M. (1982). Uptake of Ca2+ by isolated secretory vesicles from adrenal medulla.. Biochimica et biophysica acta, 691 (1), 61-70.
Gratzl, M., Krieger-Brauer, H., & Ekerdt, R. (1981). Latent acetylcholinesterase in secretory vesicles isolated from adrenal medulla.. Biochimica et biophysica acta, 649 (2), 355-66.
Krieger-Brauer, H., & Gratzl, M. (1981). Influx of Ca2+ into isolated secretory vesicles from adrenal medulla. Influence of external K+ and Na+.. FEBS letters, 133 (2), 244-6.
Pitta Bauermann, L., Gratzl, M., Kimmel, G., Surles, J., & Schindler, R. (1981). Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (epsilon-caprolactone), and their copolymers in vivo.. Biomaterials, 2 (4), 215-20.
Ekerdt, R., Dahl, G., & Gratzl, M. (1981). Membrane fusion of secretory vesicles and liposomes. Two different types of fusion.. Biochimica et biophysica acta, 646 (1), 10-22.
Gratzl, M., Torp-Pedersen, C., Dartt, D., Treiman, M., & Thornton, A. (1980). Isolation and characterization of secretory vesicles from bovine neurohypophyses.. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361 (11), 1615-28.
Gratzl, M., Ekerdt, R., & Dahl, G. (1980). The role of Ca2+ as a trigger for membrane fusion.. Hormone and metabolic research. Supplement series, Suppl 10 (), 144-9.
Pitta Bauermann, L., Gratzl, M., Jeffcoat, A., Zweidinger, R., & Schindler, R. (1979). Sustained drug delivery systems II: Factors affecting release rates from poly(epsilon-caprolactone) and related biodegradable polyesters.. Journal of pharmaceutical sciences, 68 (12), 1534-8.
Dahl, G., Ekerdt, R., & Gratzl, M. (1979). Models for exocytotic membrane fusion.. Symposia of the Society for Experimental Biology, 33 (), 349-68.
Dahl, G., Schudt, C., & Gratzl, M. (1978). Fusion of isolated myoblast plasma membranes. An approach to the mechanism.. Biochimica et biophysica acta, 514 (1), 105-16.
Gratzl, M., & Dahl, G. (1978). Fusion of secretory vesicles isolated from rat liver.. The Journal of membrane biology, 40 (4), 343-64.
Gratzl, M., Dahl, G., Russell, J., & Thornton, A. (1977). Fusion of neurohypophyseal membranes in vitro.. Biochimica et biophysica acta, 470 (1), 45-57.
Ruffalo, M., & Gratzl, M. (1976). Binding of nitroxide stearate spin labels to bovine serum albumin.. Biochimica et biophysica acta, 446 (1), 134-42.
Gratzl, M., & Dahl, G. (1976). Ca2+-induced fusion of golgi-derived secretory vesicles isolated from rat liver.. FEBS letters, 62 (2), 142-5.
Gratzl, M. (1975). Membrane effects on hepatic microsomal glucose-6-phosphatase.. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 356 (6), 861-5.
Girmann, G., Gratzl, M., Pees, H., Seebach, H., & Scheurlen, P. (1975). [Contribution to the aetiology of "reversible hepatic dysfunction" (Stauffer's syndrome) associated with renal tumours].. Deutsche medizinische Wochenschrift (1946), 100 (10), 480-4.
Deutschmann, G., Gratzl, M., & Ullrich, V. (1974). Binding of bromosulphthalein to serum albumins.. Biochimica et biophysica acta, 371 (2), 470-81.
Gratzl, M., & Schwab, D. (1974). Proceedings: Different intramembranous location of two microsomal enzymes.. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 355 (10), 1198.
Betz, H., Gratzl, M., & Remmer, H. (1973). [Inactivation of microsomal proteins by lysosomes (author's transl)].. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 354 (5), 567-75.